What People Say

“We had Chris speak as a keynote at one of our conferences. His talk was loved by our audience. He is a complete professional and made sure to communicate before and after the meeting to ensure he fit the needs of our conference. He is a great speaker!”

-Scott Becker, Becker’s Healthcare

“By lifting the shield that protects his heart, Dr. DeRienzo provides a rare glimpse into what it means to be both human and a doctor. He proves that as physicians we do not have to check our souls at our patients’ doors, and his stories give readers hope that healthcare can be healed.”

—Dr. Bridget Duffy, Cleveland Clinic’s first-ever CXO

Praise for Tiny Medicine

Tiny Medicine is an important book and should be required reading for everyone in the healthcare field … it inspires us with real-world examples of humanity’s hope, perseverance, dedication, and hope.”

—Eric Langshur, New York Times Bestselling Author of Start Here: Master the Lifelong Habit of Wellbeing

“This is a must read for anyone interested in peeking behind the curtain of modern healthcare into the real world of tiny medicine.”

Nate Klemp, PhD, Co-Founder of Life XT and New York Times Best Selling Author

“Tiny Medicine is a wonderfully honest, vulnerable, insightful, and brilliantly written book. I can’t recommend it enough!”

5 Star Verified Review

“This book is for anyone that is interested in incredible stories about survival against the odds, and the people that ensure that they do.”

5 Star Verified Review


Reach out below to get in touch with Chris for speaking engagements, book events, media inquiries, advisory board or consulting requests, or just to say hi!


Dr. Chris DeRienzo is a dedicated husband, a proud father, a mediocre triathlete, and author of the multi-category #1 Best Seller Tiny Medicine: One Doctor’s Biggest Lessons from His Smallest Patients (available in paperback).  He’s also a physician committed to improving America’s health, a frequent keynote speaker, and an advisor to companies ranging from early stage to the Fortune 50.

Recognized by Modern Healthcare, Becker’s, and Triangle Business Journal, Dr. DeRienzo loves bringing together the people, process and technology needed to drive transformation. He currently serves System Chief Medical Officer and SVP of WakeMed Health & Hospitals, where he leads the system’s Clinical Transformation portfolio and is a practicing neonatologist. Outside WakeMed, Chris serves on Board Committees / Board Advisory Councils for Premier, Inc. (NASD: PINC), the American Hospital Association, and Mercy Health (Chesterfield, MO).

Chris’s previous roles include serving as Chief Quality Officer for Mission Health, a $2B non-profit health system formerly based in Asheville, NC.  His leadership there helped infuse data-driven, analytics-enabled transformation throughout the organization, propelling Mission back to recognition by IBM Watson as a Top 15 Health System in both 2017 and 2018.  He also served as Chief Medical Officer of AI-based company Cardinal Analytx, where he led the company’s clinical and health economics portfolios through a period of significant growth and a $22 million funding round.

Chris lives with his family, two incredibly energetic dogs, and an ever-expanding flock of chickens in North Carolina.

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